| Pair Name | Aloe emodin, Temozolomide | ||
| Phytochemical Name | Aloe emodin (PubChem CID: 10207 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Aloe emodin, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | MGMT | hsa4255 |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| In Vitro Model | IRCC-Neuromed-NULU | Glioblastoma | Homo sapiens (Human) | CVCL_B1D1 |
| IRCC-Neuromed-ZAR | Glioblastoma | Homo sapiens (Human) | CVCL_B1CY | |
| Result | These convincing results suggest that AE could be a natural adjuvant agent to potentiate the effects of traditional drugs (TMZ) and overcome drug resistance in glioblastoma cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Aloe-Emodin Overcomes Anti-Cancer Drug Resistance to Temozolomide and Prevents Colony Formation and Migration in Primary Human Glioblastoma Cell Lines NULU and ZAR. Molecules. 2023 Aug 11;28(16):6024. doi: 10.3390/molecules28166024 | Click |
